Integrative Physiology

Fields of Research

Focus

We investigate the role of redox signaling in both physiological and pathological contexts. Our research spans multiple biological scales from cellular differentiation to complex systemic effects, focusing on cancer, bone remodeling disorders, and cardiovascular pathophysiology. By integrating experimental techniques and diagnostic data with advanced computational modeling, we aim to advance understanding of how redox mechanisms contribute to homeostasis or drive disease onset and progression.

Related People

Haixia Wu

PhD student

Katrin Schröder

Prof. Dr. / Professor

Manuela Spaeth

Technician

Highlighted Publications

NOX4 contributes to the initiation and progression of AAA in a cell type-specific manner

medRxiv ( Mar 2026)

NoxO1 promotes endosome formation and reduces intracellular vesicle processing

Redox Biol. (Feb 2026)

Myeloid HIF1α has only a minor impact on atherosclerosis development

Vasc Biol. (Jan 2026)

The NADPH oxidase Nox4 has anti-atherosclerotic functions

Eur Heart J. (Sep 2015)

View full list

Other Fields of Research

RNA-centric gene regulatory networks

Functional proteomics of mitochondrial regulation

RNA‑driven chromatin and epigenetic programming

Vascular RNA biology

Molecular and Systems Physiology

Systems RNA Biology of fate and identity

Metabolic control of cardiovascular function

Frequently Asked Questions

Integrative physiology examines how molecular, cellular, tissue, and organ-level processes interact to sustain cardiovascular function in health and disease.

Because cardiovascular function emerges from coordinated interactions across biological scales, rather than from isolated pathways or cell types.

Cell fate and identity determine how cardiovascular cells develop, specialize, and respond to stress, linking molecular regulation to tissue organization and overall organ function.