Our long-term goal is to translate this understanding into more precise strategies to prevent and treat cardiovascular complications. By clarifying how cells, signals, and mechanics coordinate the patterning and remodeling of vessels and myocardium, we seek to inform, innovate, and ultimately develop novel interventions that preserve or restore vascular integrity and cardiovascular function in vulnerable patients.

VRC Frankfurt unites complementary experimental and computational approaches in a single, coherent framework. We develop and deploy genetic tools to visualize and manipulate molecules, complexes, and cells with spatial and temporal control, using in vivo models such as mouse together with ex vivo and in vitro systems, including human iPSC-based differentiation and organoid models that mimic human development and disease.

We envision VRC Frankfurt as a reference point for cardiovascular research: a place where complex questions about the vasculature and heart can be followed seamlessly from mechanism to physiology to potential intervention.

We employ a holistic approach to cardiovascular science, systematically navigating molecular and foundational principles alongside organ- and whole-body physiology. Our work moves seamlessly from chromatin and RNA to cells, tissues, and circulation, drawing on engineered human tissues, advanced imaging, in vivo physiology, and computational analysis. By working across scales, we seek to pinpoint cardiovascular vulnerabilities, measure them precisely, and reshape them to protect patients.